ecopa | databases
	Databases (information kindly provided by The Norwegian Reference Centre for Laboratory Animal Science & Alternatives, and updated by the NCA) Altweb Altweb functions as a portal to information on the 3Rs. It provides information on databases (Altweb Anesthesia/Analgesia Database, Altweb Humane Endpoints Database and links to others), has its own extensive 3Rs search engine, full text journals on-line, etc. AVAR The Association of Veterinarians for Animal Rights (AVAR) at the University of California, Davis, California, USA has made a database of information on alternatives to the use of animals in teaching, predominantly for the American market. Copies of the database can be downloaded from the Internet. ECVAM ECVAM plans to develop a database to support validation studies carried out under their auspices. This will initially provide information on test development, prevalidation, test protocols and test chemicals, data and data analysis, background documentation and the progress of regulatory access. Some public access may later be permitted to data on completed studies. A hotline datalink for exchange of data via the Internet between participating laboratories is also planned, as is a register of scientists working in the area of in vitro pharmatoxicology. Further details from: Annett Janusch, ECVAM, JRC Environmental Institute, I-21020 Ispra (VA), Italy Telephone: +39 332 785 570 Telefax: +39 332 789 963 Email: annett.janusch@ei.jrc.it Website: ecvam-sis.jrc.it/ Federal Veterinary Office, Bern, Switzerland The documentation service of the Department of Animal Experimentation and Alternative Methods (STA) maintains a database of all animal experiments performed in Switzerland since 1992. There is no public access to this information, but information is provided from a 2000-record database of literature on husbandry, alternatives and the ethics of animal experimentation. Further details from: Michelle Howald, Swiss Federal Veterinary Office, Animal Welfare Division, Animal Expermentation and Alternative Methods Section, Schwarzenburgstrasse 161, CH-3003 Bern, Switzerland Telephone: +41 31 323 8563 Telefax: +41 31 323 8570 Email: michelle.howald@bvet.admin.ch ILAR ILAR maintains the international database on Laboratory Registration Codes, and can also offer some help to people wishing to locate animals or genetic materials for research. INVITTOX This service provides protocols for methods of in vitro toxicity testing at a level of detail not normally found in the published literature. The 114 available protocols include SOP's from recent validation studies coordinated by ECVAM. A total of 650 scientists, mainly from academia and industry, are registered to use the services of INVITTOX. INVITTOX has been funded by DGXI and by ECVAM. INVTTOX can be consulted on the ECVAM scientific information services page: http://ecvam-sis.jrc.it/ The Swiss 3R Research Foundation The Swiss 3R Research Foundation provides information on 3R-Projects supported by the Foundation. Updated abstracts from more than 80 projects are presented and ordered according to topics. see: http://www.forschung3r.ch/en/projects/index.html For further details please contact: Prof. Dr. Peter Maier Scientific Adviser 3R Research Foundation Dorfplatz 5, CH-3110 Münsingen, Switzerland Email: research.3r@bluewin.ch Fax: +41-(0)31-722 08 34 Homepage: www.forschung3r.ch The MEIC project The MEIC project (Multicentre Evaluation of In vitro Cytotoxicology) has involved 50 laboratories using 96 in vitro methods to test the toxicity of between 20 and 50 defined chemicals. The results are in the process of being published in ATLA and will also be available via the Internet. MEIC has also collected data on time-related high survived and lethal blood concentrations from cases of human poisoning and has published this information in a monograph for each test chemical to facilitate in vitro and in vivo comparison. MEIC in vitro database In MEMO, (in vivo database) literature research has been combined by collaboration with interested poison information centers and medico-legal institutes, to collect unpublished case reports as well. A new system for tabulation of collateral data, necessary to interpret the concentrations, has been developed. The ultimate goal has been to establish scatter plots of time-related toxic ( high survived ) and lethal blood concentrations, to permit a drawing of LC-100, LC-0 and LC-50 curves. Finally, we have obtained LC-50 curves for most chemicals. The Netherlands Centre for Alternatives to Animal Use (NCA) The Netherlands Centre for Alternatives to Animal Use (NCA) provides a database on projects on the 3Rs in the Netherlands. Further details from: Jan van der Valk, The Netherlands Centre for Alternatives to Animal Use, Dept. DWM, PO Box 80.166, NL-3508 TD Utrecht, The Netherlands Telephone: +31 30 253 2186 Telefax: +31 30 253 9227 Email: valk@vet.uu.nl The NORINA database of audiovisuals and other alternatives in education (3) NORINA (A Norwegian Inventory of Alternatives) provides information on over 3500 audiovisual aids and other alternatives such as computer programs to the use of animals or animal products in teaching, at all levels from junior school to university. NORINA is available online on the WWW. So far, there is one mirror site, in Sydney, Australia. Further mirror sites are being sought. Individual copies of NORINA for IBM or Macintosh computers may also be purchased at non-profit prices. For more information please contact Karina Smith (email: karina.smith@veths.no) or Adrian Smith (email: adrian.smith@veths.no). The Tree of Life The Tree of Life is an Internet project containing information about phylogeny and biodiversity. It is designed to illustrate the diversity of living organisms, and to link biological information available on the Internet in the form of a phylogenetic navigator. University of California Center for Animal Alternatives The UC Center for Animal Alternatives serves the animal care community of the University of California's nine campuses and laboratories, focussing mainly on alternatives in education and the issues surrounding the third R, Refinement. It also acts as a referral service, providing information on how best to search for required information. The Center publishes a newsletter, UC Alert, and guides to information resources. The site gives on overview of databases which are useful when searching for alternatives, as is required by USDA Policy 12. There are others which may be useful as well. While not all are required to be searched for every protocol, the most appropriate databases searched will depend on both the research and the animal model. The ZEBET database The ZEBET database contains documentation on about 300 alternatives in all fields of biomedicine and contains a total of about 4000 bibliographical references. ZEBET is used to provide advice and information to scientists and animal welfare officers during the process of licensing applications for animal experimentation. In controversial cases, ZEBET makes an official statement to the regional authorities which may be used in court cases. ZEBET also handles more general queries on alternatives from all sectors of society. A trial is in progress to investigate the feasibility of offering public access to the database through DIMDI. The following literature reference is also recommended: Alternatives to animal testing: information resources via the internet and world wide web, by P.J. Hakkinen and D.K. Green, published in Toxicology, Vol. 173(1-2), 3-11, April 2002. More databases can be found on the NCA website.
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